GFR Estimation

Glomerular filtration rate (GFR) is usually accepted as the best overall index of kidney function in health and disease.

The level of GFR and its magnitude of change over time are vital to the detection of kidney disease, understanding its severity and for making decisions about diagnosis, prognosis and treatment, including drug dosing. GFR is measured using plasma or urinary clearance of exogenous filtration markers. It is a cumbersome procedure and can only be performed in specialized centers in specific circumstances. GFR is therefore usually estimated from endogenous filtration markers.

Estimating equations

• Creatinine-based equations
• Cystatin C-based equations
• Panel eGFR equations
• Approach to GFR evaluation
• GFR calculators
• NKF frequently asked questions about GFR estimates
• Downloadable script for calculating eGFR using SAS or R statistical software
• Implementation of 2021 CKD-EPI equations

2022 Clinical Research Forum Top 10

Lesley Inker, MD, received the Clinical Research Forum Distinguished Clinical Research Achievement Award in 2022.

The award recognizes CFD-EPI's research on new creatine and cystatin c-based equations to estimate GFR without race. Dr. Inker is a recognized leader in the field of kidney function evaluation. She has authored more than 100 publications on kidney health.

Dr. Lesley Inker and other Top 10 Clinical Research Achievement Awardees

AGES-Kidney research group, CKD-EPI GFR collaborators