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clinical trial
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We propose to develop an economic in-office pain tests that may help screen and differentiate patients with neuropathic corneal pain (NCP) that could be used at any ophthalmic office. These five in-office pain tests include response with filter glasses, moisture googles, cold saline, hypertonic saline and topical proparcaine.

clinical trial
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Collection of TRV and RVOT VTI from TEE and right heart pressures and CO from PA catheter.

clinical trial
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The study is seeking to create a repository of blood samples from participants who have a history of testing positive for COVID-19 to help accelerate current and future COVID-19 research.

clinical trial
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This is a prospective, multi-center, single-arm, early feasibility study that aims to evaluate the safety of the Impella BTR™ in adult patients requiring left-ventricular hemodynamic support, and to evaluate the effectiveness of the Impella BTR™ in supporting patients to recovery or their next therapy.

clinical trial
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The primary objective for this early feasibility study is to assess safety and feasibility of the Impella ECP device in adult patients undergoing an elective high-risk percutaneous coronary intervention. To assess safety, special attention is being paid to the effect of the pump on the aortic valve

clinical trial
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We are investigating whether or not use of TENS device during IUD insertion reduces pain. We will record pain scores at different points in the IUD insertion procedure for patients who choose to use the TENS device and those who do not as part of this study. TENS device uses stickers (electrodes) on the skin to give gentle electrical pulse which has been shown to help with pain in some settings. This has not been studied for use with IUD insertion.

clinical trial
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The goal of this protocol is to validate a non-contact technology with miniaturized radar integrated with a visible camera in a high-risk neonatal population to ultimately provide a safe alternative to current standard contact vital sign monitoring systems.

clinical trial
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This is a study to determine if a video that utilizes a peer to teach self administration of subcutaneous depot medroxyprogesterone is both effective and well accepted by adolescent patients who are already receiving ongoing treatment with depot medroxyprogesterone by a medical provider via an inter muscular injection.  Self administration can be done at home and therefore offers an alternative to traveling to a medical office.

clinical trial
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We are doing a research study to test a technology called spectroscopy that uses a special light and computer to better “see” where cancer is during surgery. We want to see if it can make surgery for mouth and throat cancer more effective by letting the doctor know if there are any cancer cells left behind during surgery.

clinical trial
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Aortic stenosis (AS) affects over 12.6 million adults and causes an estimated 102,700 deaths annually. There is interest in novel approaches to identify valve disease earlier the disease course before symptoms occur. We previously used machine learning (ML) to develop a system for fully automated AS screening. Here we are validating the performance of this new method for identifying AS.

clinical trial
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The purpose of this study is to find out about the safety and efficacy of VK2809 for the treatment of non-alcoholic steatohepatitis (NASH).

clinical trial
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Recent studies have shown that the causative agent of Lyme disease, the organism (Borrelia burgdorferi), may persist in animals after antibiotic treatment and can be detected by using natural tick vector (Ixodes scapularis) to acquire the organism through feeding (xenodiagnosis). The aim of this study is to investigate the utility of xenodiagnosis for identifying persistence of infection with B. burgdorferi in treated human Lyme disease.

Patient Stories
October 30, 2023
When her beloved older sister Mary was diagnosed with breast cancer at just 28, Annie Zitzow Galante knew she had to get serious about cancer screenings. She started her annual mammograms at MelroseWakefield Hospital in her twenties and never missed an exam. By the time Annie received a breast cancer diagnosis at 43, her 21-year-old daughter Laura was eager to begin her own mammograms but was deemed too young for insurance to cover them.
Articles
November 21, 2024
Tufts Medical Center orthopaedic surgeon Daniel Sun, MD, shares what you need to know about the osteoarthritis—causes, symptoms and treatments.
clinical trial
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The total duration of this study for each participant is approximately 28 weeks, which includes a screening period of 4 weeks, followed by a 24-week double blind placebo-controlled treatment period. At the end of the treatment period, all participants will have the option to enter a separate study, the blinded extension study

clinical trial
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This is a phase 2 study that evaluates Lorundrostat in adults with Hypertension, Chronic Kidney Disease, and Albuminuria.

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