About
During pregnancy, perturbations of the intrauterine environment can reshape the developmental trajectory of the fetus and predispose the offspring to significant morbidities later in life. The mechanisms involved in this complex “reprogramming” process of fetal organs are currently largely unknown.
By applying genomic analysis to placental transcriptomes, we aim to identify placental changes associated with pregnancy-related morbidities. Furthermore, we plan to test the function of newly identified genes using placental explant models. The ultimate translational goal of this work is to develop clinical biomarkers and novel therapeutic targets.