The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.
Regiona Radiotherapy in Biomarker Low-Risk and T3N0 Breast Cancer
TAILOR RT : A Randomized Trial of Regional Radiotherapy in BIomarker Low-Risk Node Positive and T3N0 Breast Cancer
Breast cancer
All genders
35+
Recruiting now
Overview
Principal Investigator: Matthew Katz
Contact Us
Latoya Marshall
Study details
Inclusion Criteria
- Patients must be women with newly diagnosed histologically proven invasive carcinoma of the breast with no evidence of metastases, staged as per site standard of care.
- Patients with T3N0 disease are eligible
- Patients with disease limited to nodal micrometastases are eligible
Exclusion Criteria
- Patients with nodal disease limited to isolated tumour cells (pN0i+ < 0.2 mm).
- Patients with pT3N1 and pT4 disease (Note: patients with T3N0 are eligible).
- Synchronous or previous contralateral invasive breast cancer. (Patients with contralateral DCIS are eligible unless previously treated with radiation.)
Study Requirements
Active Comparator: No Regional Radiotherapy
A. Whole Breast Irradiation (WBI) following BCS or; B. No Radiotherapy (RT) following mastectomy
Interventions:
Radiation: Radiation
Other: No Radiation
Active Comparator: Regional Radiotherapy
A. WBI plus RT to the regional nodes (supraclavicular, non-dissected axillary, and internal mammary) following BCS or; B. RT to the chestwall and regional nodes (supraclavicular, non-dissected axillary, and internal mammary) following mastectomy
Interventions:
Radiation: Radiation